Induction of the DNA Repair Enzyme Uracil-DNA Glycosylase in Stimulated Human Lymphocytes―
نویسنده
چکیده
induced by PHA, but nucleotide kinase activities remain con stant despite cell proliferation. The uracil-ONA glycosylase was induced 10-fold during lym phocyte stimulation by PHA. Glycosylase stimulation was co ordinate with the induction of DNA synthesis and DNA polym erase activity. Furthermore, treatment with either actinomycin 0 or cycloheximide at maximal stimulation diminished enzyme activity after an appreciable interval. These results suggest that stable base modifications which persist in quiescent cells may be miscopied during cell activation.
منابع مشابه
Induction of the DNA repair enzyme uracil-DNA glycosylase in stimulated human lymphocytes.
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تاریخ انتشار 2006